For an oocyte to generally be ready for fertilization and expansion into an embryo, the right set of genes needs to be turned on. Namekawa suspected this pre-programming with the oocyte genome transpires in a number of stages — the initial a single commencing around the time a feminine is born. He thought that chromatin remodeling proteins did A great deal of this get the job done, by shifting spools about.
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“If we know how this chromatin condition is proven, And exactly how it pertains to oocyte high-quality, it could ultimately result in therapies for many varieties of infertility,” claims Namekawa.
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This could aid reveal why more mature women are more likely to bear small children with chromosomal Problems like Down Syndrome, where an additional duplicate of chromosome 21 finds its way into an oocyte — and afterwards, an embryo.
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